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Abnormal Newborn Screening Results and Additional Testing
If your baby’s newborn screening results are abnormal, your baby will need to have another test. Not every abnormal result means your baby has a disorder. It is important to have quick follow-up testing. Without treatment, 3MGA (3-Methylglutaconic Aciduria) can result in harmful effects soon after birth.
The Utah Newborn Screening Program will contact you and your child’s pediatrician for blood and urine testing.
The Metabolic Clinic at Primary Children’s Hospital cares for babies diagnosed with 3MGA.
About 3MGA
3MGA is a group of five disorders. The symptoms and treatment of each type of 3MGA vary. 3MGA disorders can cause harmful amounts of organic acids and toxins to build up in the body.
3MGA symptoms can include developmental delay, an enlarged and weak heart, weak muscles, delayed growth, and other complications. Early detection and proper treatment are critical for the best care possible for children with 3MGA disorders.
Frequency
The most common forms of 3MGA are Type II (Barth Syndrome) which affects one in 10,000 males and Type III which affects one in 10,000 in the Iraqi-Jewish population. 3MGA Type I, IV, and V are extremely rare.
Condition Type
3MGA is an Organic Acid Disorder.
Also Known As
3-Methylglutaconic Aciduria, 3-Methylglutaconyl CoA Hydratase Deficiency, Barth Syndrome (Type II), Costeff Optic Atrophy Syndrome (Type III), Dilated Cardiomyopathy with Ataxia (Type V)